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Alverdy, John
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overview John Alverdy, MD, has run a continuously funded NIH-funded laboratory that studies the molecular interactions of bacteria and the intestinal mucosa in order to understand how life-threatening infections arise after trauma and major surgery and during critical illness. He has developed several anti-infective polymer-based compounds that can attenuate the virulence of several multi-drug resistant pathogens that cause life threatening infections in surgical patients and works with the IME to synthesize, refine, and scale the compounds for pre-clinical testing. The Alverdy lab seeks to better understand the regulation of virulence expression among potential pathogens through investigating the characteristics of the microbial context, molecular machinery that senses that context, and ultimately the lethal combinations of virulence expression that leads to disease. The majority of our work has focused on the sense and response virulence mechanisms of Pseudomonas aeruginosa, a well characterized and clinically important pathogen. We have shown a remarkable potential for this organisms to respond to host environmental cues related to stress, ischemia, immune activation and nutrient depletion. With this core model of environmental regulation of virulence expression, we are pursuing applications in intestinal transplantation, anastomotic and radiation physiology, necrotizing enterocolitis and ischemia/reperfusion injury. We are also investigating similar sense and response mechanisms in other clinically important organisms, including Staphylococcus aureus and Candida albicans. Finally, we are interested in developing virulence-based therapies to prevent virulence activation through modifications in microenvironment of the stressed host such as phosphate repletion and polymer-mediated mucosal replacement therapies. The ultimate goal of understanding microbial virulence is to provide clinical tools to improve the care of patients. However the complexity of the host-pathogen interaction and the vast amounts of mechanistic information available constitutes a formidable barrier to translational research. Computational agent based modeling is a well suited to dynamically represent mechanistic detail in a modifiable context to recapitulate cellular behavior at the tissue, organ and patient levels.
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Concept Acute Disease
Concept Abdominal Neoplasms
Concept Actins
Concept Acid Phosphatase
Concept Activities of Daily Living
Concept Adenosine
Concept Anti-Infective Agents
Concept Antibodies, Viral
Concept Alkaline Phosphatase
Concept Acinetobacter Infections
Concept Abscess
Concept Sodium-Potassium-Exchanging ATPase
Concept Algorithms
Concept Analgesics, Opioid
Concept Bile Acids and Salts
Concept Abdominal Injuries
Concept Candida
Concept Candidiasis
Concept Carotid Artery Diseases
Concept Catheterization
Concept Cecum
Concept Cell Membrane Permeability
Concept Hypoxia
Concept Antifungal Agents
Concept Cholecystokinin
Concept Choledochostomy
Concept Analysis of Variance
Concept Computer Simulation
Concept Anti-Inflammatory Agents
Concept Antifibrinolytic Agents
Concept Barium Sulfate
Concept Base Sequence
Concept Cathartics
Concept Cell Count
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Concept Cephalosporins
Concept Bacterial Infections
Concept Bayes Theorem
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Concept Calibration
Concept Bacterial Proteins
Concept Benzhydryl Compounds
Concept Body Weight
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Concept Body Image
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Concept Chloramines
Concept Candida albicans
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Concept Ciprofloxacin
Concept Clostridium Infections
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Concept Proto-Oncogene Proteins c-met
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Concept Paneth Cells
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Concept History, 20th Century
Concept Anastomotic Leak
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Concept Transcriptome
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Concept Lectins
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Concept HSP72 Heat-Shock Proteins
Concept Kaplan-Meier Estimate
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Academic Article Characteristics of the intestinal epithelial barrier during dietary manipulation and glucocorticoid stress.
Academic Article The effect of dexamethasone and endotoxin administration on biliary IgA and bacterial adherence.
Academic Article Cholecystokinin modulates mucosal immunoglobulin A function.
Academic Article Whole gut washout for severe sepsis: review of technique and preliminary results.
Academic Article Increased type 1 fimbrial expression among commensal Escherichia coli isolates in the murine cecum following catabolic stress.
Academic Article Surgical stress, bacteria, and mucosal immune function.
Academic Article Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa.
Academic Article The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest.
Academic Article Perturbed bioelectrical properties of the mouse cecum following hepatectomy and starvation: the role of bacterial adherence.
Academic Article Hand-assisted laparoscopic surgery for cancer.
Academic Article Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation.
Academic Article Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection.
Academic Article Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: a brief report.
Academic Article Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined.
Academic Article The effects of Roux-en-Y gastric bypass surgery on body image.
Academic Article The effect of glucocorticoid administration on bacterial translocation. Evidence for an acquired mucosal immunodeficient state.
Academic Article Quality of life after gastric bypass surgery: a cross-sectional study.
Academic Article Binge eating and eating-related cognitions and behavior in ethnically diverse obese women.
Academic Article High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.
Academic Article The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface.
Academic Article Components of intestinal epithelial hypoxia activate the virulence circuitry of Pseudomonas.
Academic Article Recognition of host immune activation by Pseudomonas aeruginosa.
Academic Article Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72.
Academic Article Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells.
Academic Article Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article Depressed mood in class III obesity predicted by weight-related stigma.
Academic Article Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.
Academic Article Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier.
Academic Article Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article Duodenal switch provides superior weight loss in the super-obese (BMI > or =50 kg/m2) compared with gastric bypass.
Academic Article Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.
Academic Article Safety, feasibility, and outcome of retrievable vena cava filters in high-risk surgical patients.
Academic Article Imaging findings in Roux-en-O and other misconstructions: rare but serious complications of Roux-en-Y gastric bypass surgery.
Academic Article Predictors of patient selection in bariatric surgery.
Academic Article NOTES: a surgeon's perspective.
Academic Article Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis.
Academic Article Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis.
Academic Article Considerations for the use of the Beck Depression Inventory in the assessment of weight-loss surgery seeking patients.
Academic Article The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter.
Academic Article Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa.
Academic Article Compensatory eating disorder behaviors and gastric bypass surgery outcome.
Academic Article Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.
Academic Article Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.
Academic Article Use of double-balloon enteroscopy to perform PEG in the excluded stomach after Roux-en-Y gastric bypass.
Academic Article The use of multidisciplinary teams to evaluate bariatric surgery patients: results from a national survey in the U.S.A.
Academic Article "Identification and management of an errant antiperistaltic roux limb after total gastrectomy".
Academic Article Duodenal switch gastric bypass surgery for morbid obesity: imaging of postsurgical anatomy and postoperative gastrointestinal complications.
Academic Article Gut microbial gene expression in mother-fed and formula-fed piglets.
Academic Article Duodenal switch provides superior resolution of metabolic comorbidities independent of weight loss in the super-obese (BMI > or = 50 kg/m2) compared with gastric bypass.
Academic Article The molecular Koch's postulates and surgical infection: a view forward.
Academic Article Changes in desired body shape after bariatric surgery.
Academic Article Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon.
Academic Article Carotid-esophageal fistula following a penetrating neck injury: case report.
Academic Article Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH.
Academic Article Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate.
Academic Article Contributions of intestinal bacteria to nutrition and metabolism in the critically ill.
Academic Article Novel model to study combined effects of microorganisms and oxidants on development of intestinal necrosis.
Academic Article Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: the role of in vivo virulence activation.
Academic Article Integration of TGF-ß- and EGFR-based signaling pathways using an agent-based model of epithelial restitution.
Academic Article Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption.
Academic Article Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.
Academic Article Body mass index as a predictor of 1-year outcome in gastric bypass surgery.
Academic Article Glutamine-supplemented total parenteral nutrition improves gut immune function.
Academic Article Diet creates metabolic niches in the "immature gut" that shape microbial communities.
Academic Article High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function.
Academic Article Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans.
Academic Article Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease.
Academic Article Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.
Academic Article Mortality in retroperitoneal hematoma.
Academic Article Biliary secretory IgA levels in rats with protein-calorie malnutrition.
Academic Article Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis.
Academic Article Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype.
Academic Article The effect of nutrition on gastrointestinal barrier function.
Academic Article Causes and consequences of bacterial adherence to mucosal epithelia during critical illness.
Academic Article The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away.
Academic Article Vitamin D deficiency in preoperative bariatric surgery patients.
Academic Article Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1.
Academic Article Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function.
Academic Article Laparoscopic intracavitary debridement of peripancreatic necrosis: preliminary report and description of the technique.
Academic Article The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis.
Academic Article Outcome following gastric bypass surgery: impact of past sexual abuse.
Academic Article Psychosocial outcome of gastric bypass surgery for patients with and without binge eating.
Academic Article A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.
Academic Article Assessment of binge eating disorder in morbidly obese patients evaluated for gastric bypass: SCID versus QEWP-R.
Academic Article Who are today's bariatric surgeons and which ones join the ASBS?
Academic Article Temporary loss of limb function secondary to soft tissue calcification in a patient with rhabdomyolysis-induced acute renal failure.
Academic Article Why patients seek bariatric surgery: a qualitative and quantitative analysis of patient motivation.
Academic Article Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement.
Academic Article Diagnosis and treatment of atypical presentations of hiatal hernia following bariatric surgery.
Academic Article Polymer therapeutics move into the sepsis space.
Academic Article Avoiding colectomy during surgical management of fulminant Clostridium difficile colitis.
Academic Article History, goals, and technique of laparoscopic pancreatic necrosectomy.
Academic Article Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model.
Academic Article Total parenteral nutrition promotes bacterial translocation from the gut.
Academic Article The effect of dexamethasone administration on rat intestinal permeability: the role of bacterial adherence.
Academic Article The importance of the mucosal immune system.
Academic Article Hepatitis prevalence in trauma patients.
Academic Article Effect of commercially available chemically defined liquid diets on the intestinal microflora and bacterial translocation from the gut.
Academic Article Does a localized intra-abdominal abscess produce a positive peritoneal lavage?
Academic Article The effect of route of nutrient administration on the secretory immune system.
Academic Article Hand-assisted laparoscopic live-donor nephrectomy.
Academic Article Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen.
Academic Article Part III. Obesity.
Academic Article Effect of dietary monosaccharides on Pseudomonas aeruginosa virulence.
Academic Article The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis.
Academic Article A catheter-based suture-free approach to bilioenteric anastomosis: a pilot study.
Academic Article Murine gut microbiota and transcriptome are diet dependent.
Academic Article High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation.
Academic Article Intestinal anastomotic injury alters spatially defined microbiome composition and function.
Academic Article Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012.
Academic Article Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness.
Academic Article Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.
Academic Article Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.
Academic Article Do we really know why colorectal anastomoses leak?
Academic Article The opposing forces of the intestinal microbiome and the emerging pathobiome.
Academic Article The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012.
Academic Article Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa.
Academic Article Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak.
Academic Article Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.
Academic Article During critical illness the gut does not pass the acid test.
Academic Article Microscopic analysis: morphotypes and cellular appendages.
Academic Article Agent-based model of epithelial host-pathogen interactions in anastomotic leak.
Academic Article Stool consistency as a major confounding factor affecting microbiota composition: an ignored variable?
Academic Article C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.
Academic Article The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Characteristics and Outcomes of Complicated Intra-abdominal Infections Involving Pseudomonas aeruginosa from a Randomized, Double-Blind, Phase 3 Ceftolozane-Tazobactam Study.
Academic Article The intestinal microbiome and surgical disease.
Academic Article Prevention of Perioperative Anastomotic Healing Complications: Anastomotic Stricture and Anastomotic Leak.
Academic Article Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak.
Academic Article The gut microbiota and gastrointestinal surgery.
Academic Article The role of the microbiota in surgical recovery.
Academic Article Influence of nutrition therapy on the intestinal microbiome.
Academic Article Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats.
Academic Article Modeling Acinetobacter baumannii wound infections: The critical role of iron.
Academic Article Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.
Academic Article Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.
Academic Article Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa.
Academic Article Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".
Academic Article Smoking and Postoperative Surgical Site Infection: Where There's Smoke, There's Fire.
Academic Article Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period.
Academic Article Optimum Operating Room Environment for the Prevention of Surgical Site Infections.
Academic Article Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology.
Academic Article Preparing the Bowel for Surgery: Learning from the Past and Planning for the Future.
Academic Article Microbiome Medicine: This Changes Everything.
Academic Article Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology.
Academic Article Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.
Academic Article Hypermetabolism and Nutritional Support in Sepsis.
Academic Article De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality.
Academic Article Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.
Academic Article Bacterial colonization and succession in a newly opened hospital.
Academic Article The wound environment, microbial virulence and postoperative infection: Practical lessons for the surgeon.
Academic Article Surgeon as Basic Bench Scientist: A Play in Three Acts.
Academic Article Identification of Collagenolytic Bacteria in Human Samples: Screening Methods and Clinical Implications for Resolving and Preventing Anastomotic Leaks and Wound Complications.
Academic Article Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro.
Academic Article Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.
Academic Article International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.
Academic Article Preparing the bowel for surgery: rethinking the strategy.
Academic Article Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article Prevention of Anastomotic Leak Via Local Application of Tranexamic Acid to Target Bacterial-mediated Plasminogen Activation: A Practical Solution to a Complex Problem.
Academic Article Low-fat/high-fibre diet prehabilitation improves anastomotic healing via the microbiome: an experimental model.
Academic Article Bowel preparation under siege.
Academic Article Infliximab Does Not Promote the Presence of Collagenolytic Bacteria in a Mouse Model of Colorectal Anastomosis.
Academic Article Re-examining causes of surgical site infections following elective surgery in the era of asepsis.
Academic Article An in vitro tissue model for screening sustained release of phosphate-based therapeutic attenuation of pathogen-induced proteolytic matrix degradation.
Academic Article Involvement of the Commensal Organism Bacillus subtilis in the Pathogenesis of Anastomotic Leak.
Academic Article Comparative genetics of Enterococcus faecalis intestinal tissue isolates before and after surgery in a rat model of colon anastomosis.
Academic Article Is bariatric surgery resolving NAFLD via microbiota-mediated bile acid ratio reversal? A comprehensive review.
Academic Article Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.
Academic Article Spatial Compartmentalization of the Microbiome between the Lumen and Crypts Is Lost in the Murine Cecum following the Process of Surgery, Including Overnight Fasting and Exposure to Antibiotics.
Academic Article Can the Cecal Ligation and Puncture Model Be Repurposed To Better Inform Therapy in Human Sepsis?
Academic Article Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate.
Academic Article Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial.
Academic Article Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome.
Academic Article Sepsis and the Microbiome: A Vicious Cycle.
Academic Article Bowel preparation in colorectal surgery: the day of reckoning is here.
Academic Article Anastomotic Leak: Toward an Understanding of Its Root Causes.
Academic Article Enterococcus faecalis Is Associated with Anastomotic Leak in Patients Undergoing Colorectal Surgery.
Academic Article Case presentation and panel discussion: Critical illness.
Academic Article Spatioregional assessment of the gut microbiota in experimental necrotizing pancreatitis.
Academic Article Re-examining chemically defined liquid diets through the lens of the microbiome.
Academic Article Influence of the Microbiome on Anastomotic Leak.
Academic Article Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells.
Academic Article Misinformation About the Human Gut Microbiome in YouTube Videos: Cross-sectional Study.
Academic Article Letter to the Editor: Between-Group Comparison Fallacy.
Academic Article Association Does Not Equal Causation-Does Thinking You Are Better Make You Better?
Academic Article Defeating Cancel Culture in Surgical Site Infection Research: A Plea to Include Microbial Cultures and Antibiotic Sensitivity Data.
Academic Article Pitfalls and Traps in the Surgical Evaluation of Patients with Irritable Bowel Syndrome (IBS).
Academic Article Harnessing the Microbiome to Optimize Surgical Outcomes in the COVID-19 Era.
Academic Article Updates in Prevention of Surgical Site Infection: Reply.
Academic Article Biologically inspired gastrointestinal stapler design: "Getting to Zero" complications.
Academic Article To Operate or Not? Balancing Advanced Imaging, Machine Learning, and the Doctor-Patient Relationship in Complex Clinical Decision Making.
Academic Article The Role of the Gut Microbiome on the Development of Surgical Site Infections.
Concept Clinical Decision-Making
Concept Solute Carrier Family 22 Member 5
Concept Surgical Wound
Concept Contraindications
Concept Zonula Occludens-1 Protein
Concept Carcinogenesis
Concept Dysbiosis
Concept Non-alcoholic Fatty Liver Disease
Concept In Vitro Techniques
Concept Protective Factors
Concept ErbB Receptors
Grant Serial Endoscopic Surveillance (SES) and Direct Topical Antibiotics (DTA) to prev
Grant Interplay of diet and the metabolome in establishment of the juvenile gut microbi
Academic Article Rationale for Colonic Pre-Habilitation Prior to Restoration of Gastrointestinal Continuity.
Academic Article The role of dietary prehabilitation on anastomotic healing.
Academic Article Studies Involving Surgical Site Infections (SSIs) Without Culture Results, the Antibiotics Chosen for Prophylaxis and Antibiotic Sensitivity Data: "Are they Actionable?"
Academic Article Letter to a Young Surgeon During Coronavirus Disease 2019.
Academic Article Expert Commentary on Perioperative Malnutrition.
Academic Article Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery.
Academic Article Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Academic Article Invited Commentary: Scientific Rationale behind Intestinal Alkaline Phosphatase Administration to Enhance Recovery after Pancreaticoduodenectomy.
Academic Article Commentary on: Role of Microbiome in the Outcomes Following Surgical Repair of Perianal Fistula: Prospective Cohort Study Design and Preliminary Results.
Academic Article IDEAL Phase 2a Results: Posterior Rectus Sheath Flap for Hiatal Augmentation in Complex Paraesophageal Hernias.
Academic Article Social determinants of health, the microbiome, and surgical injury.
Academic Article Comment on: Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Academic Article Neurocognitive Testing, Retirement and Self-Awareness: It's Just Another Judgement Call.
Academic Article Where do the pathogens that cause surgical site infections come from?
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